It all started when Charlie Logan was 10 years old. Breaking the cardinal rule of spin-the-bottle, Charlie refused to kiss a demented Goth girl - and she put a hex on him. Now, 25 years later, Charlie (Dane Cook) is a successful dentist... and still cursed. While his plastic surgeon best friend, Stu (Dan Fogler), pursues many his patients, Charlie can't seem to find the right girl. Worse, he discovers that every woman he's ever slept with has found true love - with the next guy after him. Before he knows it, Charlie's reputation as a "good luck charm" has women - from sexy strangers to his overweight receptionist - lining up for a quickie. However, a life filled with sex and no love has Charlie lonelier than ever - until he meets Cam (Jessica Alba). Charlie realises he's got to find a way to break his curse... before the girl of his dreams winds up with the next guy she meets.